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Post Parturient Haemoglobinuria

It is disease of high producing animals. It occurs after parturition and is characterized by straining during defecation, red urine, hemoglobinurea, anemia; and death may occur in this disease.

The major cause of this disease is phosphorus deficiency. It is more common in buffalo as compared to cattle.

Predisposing factors:

  • The diet deficient in phosphorus leads to post parturient hemoglobin urea.

  • There is deficiency of phosphorus in plants like turnips, brassica, reddish leaves and beat pulp.

  • Usually animal in 3rd – 4th lactation are more prone to this disease as compared to in first, second lactations.

  • Deficiency of copper in soil. Copper is essential part of an enzyme dismutase which is necessary for hemopoiesis.

  • Animal in dry period have normal phosphorus. But lactating animals have deficiency of phosphorus and calcium. So more prone to it.

  • It is more common 2-4 weeks after parturition. Incidence of this disease is low but mortality upto 50 %. This disease does not occur in beef cattle.

  • Ingestion of cold water also leads to hemolysis.

Clinical Findings:

  • Hemoglobinuria

  • Lack of appetite   

  • Weakness develop suddenly

  • Severe depression of the milk yield 

  • Dehydration develops quickly

  • Pale mucous membrane

  • Temperature 103.5 oF

  • Feaces dry and firm

  • Low oxygen carrying capacity of RBCs will not fulfill the requirement of oxygen; there will be increase heart rate and respiration. So there will be difficult breathing and fast heart rate.

  • In later stages there is jaundice

  • Pica may be present

  • Course of disease is 3-5 days

  • Animal becomes stagger, weak and recombinant.

Through clinical pathology, signs and symptoms.


  • Best treatment is blood transfusion upto 5 litres.

  • Sodium acid phosphate Na2H2PO4 60 g/300 ml water of which is given through intravascularly or subcutaneously. Repeat after 12 hours. Route of administration depends upon the severity of disease. 100 g Na2H2PO4 orally can be given for 5 days.

  • CuSO4 (acidified) 1-2 g orally for 10-15 days. It helps in hemopoiesis.

  • B-complex, dextrose (if dehydration)

Avoid feeding Crusiferous plants. But if have to be given then also give wheat bran (phosphorus rich diet) along with it.


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