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Ketosis |
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Ketosis occurs when there is deficiency of glucose. There is high
incidence in high producing animals because they have negative
energy balance as energy is utilized for milk synthesis. They
require balanced diet for producing good milk. So whenever glucose
is utilized in the form of lactose and no glucose available then
hypoglycemia occurs. Then protein and fat of body will be utilized
and there will be formation of ketone bodies. There are three types
of ketone bodies: acetoacetic acid, β hydroxy butyric acid, and
acetone. These produce ketonemia and ketouria. Normal ketogenic and
glucogenic ratio is equal. In ketosis ketogenic acids are 4 times
higher than propionic acid.
Huge
shift of energy from dam to offspring occurs after parturition and
animal goes in negative energy balance. Adrenal gland disfunction
leads to deficiency of glucose due to lack of glucocorticosteroids
and cortisole. Hypothyroidism leads to increased metabolism of
glucose, protein and fat causing hypoglycemia and ultimately
ketosis. Hay and silage also have ability to produce VFAs but hay is
less ketogenic and silage is more. Silage contains more butyric
acid. Starvation also leads to ketosis. |
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Predisposing Factors of Primary Ketosis:
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Animal fed inadequate rations
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Some nutritional deficiency of soil
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Genetics
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Deficiency of TDN
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Deficiency of vitamin B12
Predisposing Factors of Secondary ketosis:
Clinical Findings:
Wasting Form:
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It is the most common form
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It is manifested by moderate decrease in diet
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Milk yield low for 2-4 days. 25 % loss in milk production
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Refuse silage but accept hay and then totally deprived of hay
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Rapid loss in body weight
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Body coat becomes thin
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Due to loss of subcutaneous fat there is no elasticity
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Zero subcutaneous fat may occur and you can name it as woody
appearance
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Feaces are firm and dry
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Utilization of body protein and fat.
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Animal may have constipation
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Cow is depressed and gives appearance of hang lock, hypoglycemia
is the cause of it
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Cow is unable to move and cannot eat properly
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Temperature and respiration are normal but have low ruminal
movements
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In wasting form mild type of nervous signs may found in some
cases like staggering gait and partial blindness.
Nervous form:
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Animal walk in circle
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May cross its legs
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Head pushing
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Apparent blindness
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Animal move aimlessly and may wander
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Licking of skin and inaminate objects (pica)
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Loss of appetite, chewing movement with salivation
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Animal may be off feed but still chew with salivation
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Hyperesthesia (animal may become excited)
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Ballowing
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Muscle tremor
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Tetany
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Incoordinated gait
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Nervous signs last for 2 hours and after that become normal and
reoccur after 8-10 hours of first onset. During this cow may
injure itself by falling on ground.
Diagnosis:
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It is based on clinical findings.
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Kit is available. There are strips available in the form of
Rhoter’s reagent. Normal color is yellow; if changed to red,
ketosis.
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Weight loss, fall in glucose level indicates ketosis. In
secondary ketosis there is abomasal displacement, partial
anorexia and less feaces.
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In suclinical ketosis Ketone bodies are 20-40 mg/dl. In clinical
ketosis, ketone bodies upto 100 mg/dl.
Treatment:
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500 g/litre of N.S or ringer lactate.
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Glycerin (oral) 220 g/day for two days
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NaHCO3 or ringer to lessen acidosis.
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Copyrights © Dr. M Jassar
Aftab, All Rights Reserved |
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